80 results on '"Ryan, Dermot P."'
Search Results
2. Prioritising primary care respiratory research needs: results from the 2020 International Primary Care Respiratory Group (IPCRG) global e-Delphi exercise
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Abdel-Aal, Arwa, Lisspers, Karin, Williams, Siân, Adab, Peymané, Adams, Rachel, Agarwal, Dhiraj, Barnard, Amanda, Bouloukaki, Izolde, van Boven, Job F. M., Chavannes, Niels, Dickens, Andrew P., van Gemert, Frederik, Escarrer, Mercedes, Haroon, Shamil, Kayongo, Alex, Kirenga, Bruce, Kocks, Janwillem W. H., Kotz, Daniel, Newby, Chris, McNulty, Cliodna, Metting, Esther, Moral, Luis, Papadakis, Sophia, Pinnock, Hilary, Price, David, Ryan, Dermot, Singh, Sally J., Correia de Sousa, Jaime, Ställberg, Björn, Szefler, Stanley J., Taylor, Stephanie J. C., Tsiligianni, Ioanna, Turner, Alice, Weller, David, Yusuf, Osman, Tabyshova, Aizhamal K., and Jordan, Rachel E.
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- 2022
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3. The Experiences of American International Students in a Large Irish University
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O'Reilly, Aileen, Hickey, Tina, and Ryan, Dermot
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Growing numbers of American students are travelling overseas to study abroad and enroll in full degree programs. Despite this trend, relatively little is known about the experiences of United States (U.S.) students abroad. The aim of this research was to examine the experiences of American international students in Ireland. Findings suggest that while U.S. students experience some adaptation problems, overall, they adapt well to studying in Ireland. Subtle differences in long-term and short-term international students' levels of social support and academic satisfaction were also detected. This research has important practical implications for facilitating the adaption of U.S. students abroad. At a time when many governments and academic institutions are devising strategies to attract international students, this research is timely and necessary.
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- 2015
4. Hormonal contraception and the risk of severe asthma exacerbation: 17-year population-based cohort study
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Nwaru, Bright I, primary, Tibble, Holly, additional, Shah, Syed A, additional, Pillinger, Rebecca, additional, McLean, Susannah, additional, Ryan, Dermot P, additional, Critchley, Hilary, additional, Price, David B, additional, Hawrylowicz, Catherine M, additional, Simpson, Colin R, additional, Soyiri, Ireneous N, additional, Appiagyei, Francis, additional, and Sheikh, Aziz, additional
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- 2020
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5. Use of immobile trace elements in gold exploration in the Neoarchean Sandstone Greenstone Belt, Yilgarn Block, Western Australia
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Jia, Changshun, Groves, David I., Kammermann, Michael S., Ryan, Dermot M., and Davies, Rhys S.
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- 2020
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6. A multinational observational study identifying primary care patients at risk of overestimation of asthma control
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Kritikos, Vicky, Price, David, Papi, Alberto, Infantino, Antonio, Ställberg, Bjorn, Ryan, Dermot, Lavorini, Federico, Chrystyn, Henry, Haughney, John, Lisspers, Karin, Gruffydd-Jones, Kevin, Román Rodríguez, Miguel, Høegh Henrichsen, Svein, van der Molen, Thys, Carter, Victoria, and Bosnic-Anticevich, Sinthia
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- 2019
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7. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases
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Bousquet, J. Jean, Schünemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M., Menditto, Enrica, Mullol, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhân, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bialek, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D’Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioğlu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria-Antonieta, Hajjam, Jawad, O’B Hourihane, John, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Illario, Maddalena, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, De Manuel Keenoy, Esteban, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melén, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralf, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonné, O’Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schöll, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pépin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Picard, Robert, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Söderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Suppli Ulrik, Charlotte, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter V., Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stéphane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, the ARIA Study Group, and the MASK Study Group
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- 2019
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8. Drug allergy in primary care: systematic review to support quality improvement initiative of management and optimization of healthcare pathways
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Gaudin, Clara, Ryan, Dermot, Demoly, Pascal, and Tanno, Luciana Kase
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- 2023
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9. Comparison of adverse events associated with different spacers used with non-extrafine beclometasone dipropionate for asthma
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Ming, Simon Wan Yau, Haughney, John, Ryan, Dermot, Patel, Shishir, Ochel, Matthias, d’Alcontres, Martina Stagno, Thornhill, Susannah, Kocks, Janwillem W. H., and Price, David
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- 2019
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10. Higher Education Professionals' Perspectives on International Student Experiences of Life and Learning in Ireland: A Qualitative Study
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O'Reilly, Aileen, Hickey, Tina, and Ryan, Dermot
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Although numerous studies have explored international students' experiences, there is a dearth of research exploring the perspectives of professionals who have contact with international students. The present study addresses this gap in the literature by providing an analysis of higher educational professionals' ("n"=11) perspectives of international students' experiences and analysing the challenges which arise when working with international students. In this study, semi-structured interviews were conducted with staff from a large Irish Higher Education Institution. Participants described a range of difficulties experienced by international students, including sociocultural and psychological difficulties, and outlined a number of challenges which exist when dealing with international students, most of which relate to cultural differences and lack of interest in internationalisation. The findings have important policy and practical implications for higher education service provision and point to the need to consider internationalisation as a process which can be enriching for international students, host students and staff members alike.
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- 2013
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11. The Psychological Well-Being and Sociocultural Adaptation of Short-Term International Students in Ireland
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O'Reilly, Aileen, Ryan, Dermot, and Hickey, Tina
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This article reports on an empirical study of the psychosocial adaptation of international students in Ireland. Using measures of social support, loneliness, stress, psychological well-being, and sociocultural adaptation, data were obtained from international students and a comparison sample of Irish students. The study found that, although international students had high levels of social support and low levels of loneliness and stress, students were experiencing high levels of sociocultural adjustment difficulties and psychological distress. Significant differences invariables were reported across time, whereas differences between international and Irish students were also discovered. Suggestions for further research and for individuals working with international students are proposed. (Contains 3 tables.)
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- 2010
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12. John Diarmuid Ryan
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Ryan, Dermot P. and Ryan, Brendan
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- 2000
13. The International Primary Care Respiratory Group (IPCRG) Research Needs Statement 2010
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Pinnock, Hilary, Thomas, Mike, Tsiligianni, Ioanna, Lisspers, Karin, østrem, Anders, Ställberg, Björn, Yusuf, Osman, Ryan, Dermot, Buffels, Johan, Cals, Jochen WL, Chavannes, Niels H, Henrichsen, Svein Høegh, Langhammer, Arnulf, Latysheva, Elena, Lionis, Christos, Litt, John, van der Molen, Thys, Zwar, Nick, and Williams, Sian
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- 2010
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14. Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review
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Bousquet, Jean, primary, Ansótegui, Ignacio, additional, Walter Canonica, G., additional, Zuberbier, Torsten, additional, Baena-Cagnani, Carlos E., additional, Bachert, Claus, additional, Cruz, Alvaro A., additional, González, Sandra N., additional, Kuna, Piotr, additional, Morais-Almeida, Mario, additional, Mullol, Joaquim, additional, Ryan, Dermot P., additional, Sánchez-Borges, Mario, additional, Valiente, Román, additional, and Church, Martin K., additional
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- 2011
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15. Sub-Lingual Immunotherapy
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Canonica, G. Walter, primary, Bousquet, Jean, additional, Casale, Thomas, additional, Lockey, Richard F., additional, Baena-Cagnani, Carlos E., additional, Pawankar, Ruby, additional, Potter, Paul C., additional, Bousquet, Philippe J., additional, Cox, Linda S., additional, Durham, Stephen R., additional, Nelson, Harold S., additional, Passalacqua, Giovanni, additional, Ryan, Dermot P., additional, Brozek, Jan L., additional, Compalati, Enrico, additional, Dahl, Ronald, additional, Delgado, Luis, additional, van Wijk, Roy Gerth, additional, Gower, Richard G., additional, Ledford, Dennis K., additional, Filho, Nelson Rosario, additional, Valovirta, Erkka J., additional, Yusuf, Osman M., additional, Zuberbier, Torsten, additional, Akhanda, Wahiduzzaman, additional, Almarales, Raul Castro, additional, Ansotegui, Ignacio, additional, Bonifazi, Floriano, additional, Ceuppens, Jan, additional, Chivato, Tomás, additional, Dimova, Darina, additional, Dumitrascu, Diana, additional, Fontana, Luigi, additional, Katelaris, Constance H., additional, Kaulsay, Ranbir, additional, Kuna, Piotr, additional, Larenas-Linnemann, Désirée, additional, Manoussakis, Manolis, additional, Nekam, Kristof, additional, Nunes, Carlos, additional, O'Hehir, Robyn, additional, Olaguibel, José M., additional, Onder, Nerin Bahceciler, additional, Park, Jung Won, additional, Priftanji, Alfred, additional, Puy, Robert, additional, Sarmiento, Luis, additional, Scadding, Glenis, additional, Schmid-Grendelmeier, Peter, additional, Seberova, Ester, additional, Sepiashvili, Revaz, additional, Solé, Dírceu, additional, Togias, Alkis, additional, Tomino, Carlo, additional, Toskala, Elina, additional, Van Beever, Hugo, additional, and Vieths, Stefan, additional
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- 2009
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16. Systematic review and meta-analysis of budesonide/formoterol in a single inhaler
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Edwards, Steven J., primary, Gruffydd-Jones, Kevin, additional, and Ryan, Dermot P., additional
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- 2007
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17. Hormone replacement therapy and asthma onset in menopausal women: National cohort study.
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Shah, Syed A., Tibble, Holly, Pillinger, Rebecca, McLean, Susannah, Ryan, Dermot, Critchley, Hilary, Price, David, Hawrylowicz, Catherine M., Simpson, Colin R., Soyiri, Ireneous N., Appiagyei, Francis, Sheikh, Aziz, and Nwaru, Bright I.
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There is uncertainty about the role of hormonal replacement therapy (HRT) in the development of asthma. We investigated whether use of HRT and duration of use was associated with risk of development of asthma in perimenopausal and postmenopausal women. We constructed a 17-year (from January 1, 2000, to December 31, 2016) open cohort of 353,173 women (aged 46-70 years) from the Optimum Patient Care Database, a longitudinal primary care database from across the United Kingdom. HRT use, subtypes, and duration of use; confounding variables; and asthma onset were defined by using the Read Clinical Classification System. We fitted multilevel Cox regression models to estimate hazard ratios (HRs) with 95% CIs. During the 17-year follow-up (1,340,423 person years), 7,614 new asthma cases occurred, giving an incidence rate of 5.7 (95% CI = 5.5-5.8) per 1,000 person years. Compared with nonuse of HRT, previous use of any (HR = 0.83; 95% CI = 0.76-0.88), estrogen-only (HR = 0.89; 95% CI = 0.84-0.95), or combined estrogen and progestogen (HR = 0.82; 95% CI = 0.76-0.88) HRT was associated with a reduced risk of asthma onset. This was also the case with current use of any (HR = 0.79; 95% CI = 0.74-0.85), estrogen-only (HR = 0.80; 95% CI = 0.73-0.87), and combined estrogen and progestogen (HR = 0.78; 95% CI = 0.70-0.87) HRT. Longer duration of HRT use (1-2 years [HR = 0.93; 95% CI = 0.87-0.99]; 3-4 years [HR = 0.77; 95% CI = 0.70-0.84]; and ≥5 years [HR = 0.71; 95% CI = 0.64-0.78]) was associated with a dose-response reduced risk of asthma onset. We found that HRT was associated with a reduced risk of development of late onset asthma in menopausal women. Further cohort studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]
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- 2021
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18. Defining a Severe Asthma Super-Responder: Findings from a Delphi Process
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Upham, John W., Le Lievre, Chantal, Jackson, David J., Masoli, Matthew, Wechsler, Michael E., Price, David B., Mansur, Adel, Detoraki, Aikaterini, Altraja, Alan, James, Alan, Nanzer-Kelly, Alexandra, Côté, Andréanne, Menzies-Gow, Andrew, Papaioannou, Andriana, Cheffins, Anne-Maree, Bourdin, Arnaud, Mahboub, Bassam, Lipworth, Brian, Celis-Preciado, Carlos Andrés, Torres-Duque, Carlos, Bucca, Caterina, Porsbjerg, Celeste, Ulrik, Charlotte, Corrigan, Chris, Taube, Christian, Farah, Claude, Katelaris, Constance, Langton, David, Ryan, Dermot, Larenas-Linnemann, Désirée, Zervas, Eleftherios, Heffler, Enrico, Hoyte, Flavia, Puggioni, Francesca, Christoff, George, Canonica, Giorgio Walter, Carpagnano, Giovanna Elisiana, Guida, Giuseppe, Katsoulotos, Gregory, Brusselle, Guy, Rupani, Hitashi, Jersmann, Hubertus, Clifton, Ian, Dhariwal, Jaideep, Fingleton, James, Duke, Jane, Rimmer, Janet, Douglass, Jo, Fonseca, João, van Boven, Job, Corless, John, Harrington, John, Maspero, Jorge, Miguel, José Luis, Pipatvech, Kanok, Kenny, Karrinda, Chapman, Kenneth, Kostikas, Konstantinos, Lehtimäki, Lauri, Chung, Li Ping, Heaney, Liam, Hang, Liang-Wen, Boulet, Louis-Philippe, Perez-de-Llano, Luis, Ricciardi, Luisa, Idrees, Majdy, Milanese, Manlio, Conte, Maria Elisabetta, Costantino, Maria Teresa, Siyue, Mariko Koh, Fitzgerald, Mark, Hew, Mark, Peters, Matthew, Tsai, Ming-Ju, Patel, Mitesh, Khan, Mohammad Hashim, Sadatsafavi, Mohsen, Al-Ahmad, Mona, Yacoub, Mona-Rita, De Gennaro, Mónica, Radhakrishna, Naghmeh, Hanania, Nicola Alexander, Papadopoulos, Nikolaos, Lugogo, Njira, Linaker, Norma, Crimi, Nunzio, Dennison, Paddy, Nair, Parameswaran, Mitchell, Patrick David, O’Byrne, Paul, Pfeffer, Paul, Kauppi, Paula, Hughes, Pauline, Middleton, Peter, Wark, Peter, Bardin, Philip, Fu, Pin-Kuei, Akuthota, Praveen, Chaudhuri, Rekha, Campos, Ricardo, Al-Lehebi, Riyard, Parente, Roberta, Francisco, Rovira, Wenzel, Sally, Pierachille, Santus, Pawar, Shrikant, Loukides, Stelios, Fowler, Stephen, Mackenzie, Tara, Brown, Thomas, Lee Tan, Tze, Björnsdóttir, Unnur, McDonald, Vanessa, Lawriwskyj, Veronica, Backer, Vibeke, Vasileva, Violina, Chien, Ying-Chun, and Harrington, Zinta
- Abstract
Clinicians are increasingly recognizing severe asthma patients in whom biologics and other add-on therapies lead to dramatic improvement. Currently, there is no agreed-upon super-responder (SR) definition.
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- 2021
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19. Hormonal contraception and the risk of severe asthma exacerbation: 17-year population-based cohort study.
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Nwaru, Bright I., Tibble, Holly, Shah, Syed A., Pillinger, Rebecca, McLean, Susannah, Ryan, Dermot P., Critchley, Hilary, Price, David B., Hawrylowicz, Catherine M., Simpson, Colin R., Soyiri, Ireneous N., Appiagyei, Francis, and Sheikh, Aziz
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MENORRHAGIA ,ATOPY ,ASTHMA ,CONTRACEPTION ,RESEARCH ,RESEARCH methodology ,RETROSPECTIVE studies ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,RESEARCH funding ,LONGITUDINAL method - Abstract
Background: Longitudinal studies investigating impact of exogenous sex steroids on clinical outcomes of asthma in women are lacking. We investigated the association between use of hormonal contraceptives and risk of severe asthma exacerbation in reproductive-age women with asthma.Methods: We used the Optimum Patient Care Research Database, a population-based, longitudinal, anonymised primary care database in the UK, to construct a 17-year (1 January 2000-31 December 2016) retrospective cohort of reproductive-age (16-45 years, n=83 084) women with asthma. Using Read codes, we defined use, subtypes and duration of use of hormonal contraceptives. Severe asthma exacerbation was defined according to recommendations of the European Respiratory Society/American Thoracic Society as asthma-related hospitalisation, accident and emergency department visits due to asthma and/or oral corticosteroid prescriptions. Analyses were done using multilevel mixed-effects Poisson regression with QR decomposition.Results: The 17-year follow-up resulted in 456 803 person-years of follow-up time. At baseline, 34% of women were using any hormonal contraceptives, 25% combined (oestrogen/progestogen) and 9% progestogen-only contraceptives. Previous (incidence rate ratio (IRR) 0.94, 95% CI 0.92 to 0.97) and current (IRR 0.96, 95% CI 0.94 to 0.98) use of any, previous (IRR 0.92, 95% CI 0.87 to 0.97) and current use of combined (IRR 0.93, 95% CI 0.91 to 0.96) and longer duration of use (3-4 years: IRR 0.94, 95% CI 0.92 to 0.97; 5+ years: IRR 0.91, 95% CI 0.89 to 0.93) of hormonal contraceptives, but not progestogen-only contraceptives, were associated with reduced risk of severe asthma exacerbation compared with non-use.Conclusions: Use of hormonal contraceptives may reduce the risk of severe asthma exacerbation in reproductive-age women. Mechanistic studies investigating the biological basis for the influence of hormonal contraceptives on clinical outcomes of asthma in women are required.Protocol Registration Number: European Union electronic Register of Post-Authorisation Studies (EUPAS22967). [ABSTRACT FROM AUTHOR]- Published
- 2021
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20. GINA 2020: Potential Impacts, Opportunities, and Challenges for Primary Care
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Kaplan, Alan, van Boven, Job F.M., Ryan, Dermot, Tsiligianni, Ioanna, and Bosnic-Anticevich, Sinthia
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In 2019, it was reported that changes to asthma management reported in the Global Initiative for Asthma (GINA) “…might be considered the most fundamental changes in asthma management in 30 years.” These changes refer to the recommendation that the treatment of asthma in adolescents and adults would no longer include short-acting ß2-agonist (SABA) only, but that people with asthma should receive either symptom-driven inhaled corticosteroids (ICS)-containing treatment (mild asthma) or daily ICS-containing treatment. The fundamental reason for this shift was driven by concerns about the risks and consequences associated with SABA-only treatment, the need to improve the day-to-day management of asthma symptoms to prevent exacerbations and emergent evidence. These recommendations have subsequently been reinforced and characterized in GINA 2020, and it is reasonable to say that they are significant, not only in terms of an asthma management framework but also as a management approach in practice. This opinion article specifically focuses on opportunities and challenges associated with the implementation of GINA 2020 in primary care practice that need to be recognized and addressed if the shift in asthma treatment paradigm is to be successfully implemented into day-to-day practice.
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- 2021
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21. Hormonal contraceptives and onset of asthma in reproductive-age women: Population-based cohort study.
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Nwaru, Bright I., Pillinger, Rebecca, Tibble, Holly, Shah, Syed A., Ryan, Dermot, Critchley, Hilary, Price, David, Hawrylowicz, Catherine M., Simpson, Colin R., Soyiri, Ireneous N., Appiagyei, Francis, and Sheikh, Aziz
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Despite well-described sex differences in asthma incidence, there remains uncertainty about the role of female sex hormones in the development of asthma. We sought to investigate whether hormonal contraceptive use, its subtypes, and duration of use were associated with new-onset asthma in reproductive-age women. Using the Optimum Patient Care Research Database, a UK national primary care database, we constructed an open cohort of 16- to 45-year-old women (N = 564,896) followed for up to 17 years (ie, January 1, 2000, to December 31, 2016). We fitted multilevel Cox regression models to analyze the data. At baseline, 26% of women were using any hormonal contraceptives. During follow-up (3,597,146 person-years), 25,288 women developed asthma, an incidence rate of 7.0 (95% CI, 6.9-7.1) per 1000 person-years. Compared with nonuse, previous use of any hormonal contraceptives (hazard ratio [HR], 0.70; 95% CI, 0.68-0.72), combined (HR, 0.70; 95% CI, 0.68-0.72), and progestogen-only therapy (HR, 0.70; 95% CI, 0.67-0.74) was associated with reduced risk of new-onset asthma. For current use, the estimates were as follows: any (HR, 0.63; 95% CI, 0.61-0.65), combined (HR, 0.65; 95% CI, 0.62-0.67), and progestogen-only therapy (HR, 0.59; 95% CI, 0.56-0.62). Longer duration of use (1-2 years: HR, 0.83; 95% CI, 0.81-0.86; 3-4 years: HR, 0.64; 95% CI, 0.61-0.67; 5+ years: HR, 0.46; 95% CI, 0.44-0.49) was associated with a lower risk of asthma onset than nonuse. Hormonal contraceptive use was associated with reduced risk of new-onset asthma in women of reproductive age. Mechanistic investigations to uncover the biological processes for these observations are required. Clinical trials investigating the safety and effectiveness of hormonal contraceptives for primary prevention of asthma will be helpful to confirm these results. [ABSTRACT FROM AUTHOR]
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- 2020
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22. Unscientific Assertions On Treating Asthma In General Practice
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Ryan, Dermot P. and Levy, Mark
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- 1994
23. Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: a randomised controlled trial.
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Price, David B, Buhl, Roland, Chan, Adrian, Freeman, Daryl, Gardener, Elizabeth, Godley, Clifford, Gruffydd-Jones, Kevin, McGarvey, Lorcan, Ohta, Ken, Ryan, Dermot, Syk, Jörgen, Tan, Ngiap Chuan, Tan, TzeLee, Thomas, Mike, Yang, Sen, Konduru, Priyanka Raju, Ngantcha, Marcus, d'Alcontres, Martina Stagno, and Lapperre, Therese S
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NITRIC oxide ,CORTICOSTEROIDS - Abstract
Summary Background Chronic non-specific respiratory symptoms are difficult to manage. This trial aimed to evaluate the association between baseline fractional exhaled nitric oxide (F e NO) and the response to inhaled corticosteroids in patients with non-specific respiratory symptoms. Methods In this double-blind randomised placebo-controlled trial, we enrolled undiagnosed patients, aged 18–80 years, with cough, wheeze, or dyspnoea and less than 20% bronchodilator reversibility across 26 primary care centres and hospitals in the UK and Singapore. Patients were assessed for 2 weeks before being randomly assigned (1:1) to 4 weeks of treatment with extrafine inhaled corticosteroids (QVAR 80 μg, two puffs twice per day, equivalent to 800 μg per day beclomethasone dipropionate) or placebo. Randomisation was stratified by baseline F e NO measurement: normal (≤25 parts per billion [ppb]), intermediate (>25 tp <40 ppb), and high (≥40 ppb). The primary endpoint was change in Asthma Control Questionnaire (ACQ7) mean score. We used generalised linear modelling to assess F e NO as a predictor of response, estimating an interaction effect between F e NO and treatment on change in ACQ7. We did our primary and secondary analyses in the per-protocol set, which excluded patients with non-completion of the primary endpoint, non-compliance to treatment (ascertained by patient report), and study visits made outside the predefined visit windows. This study is registered on ClinicalTrials.gov , number NCT02294279 . Findings Between Feb 4, 2015, and July 12, 2016, we randomly assigned 294 patients to extrafine inhaled corticosteroid treatment (n=148) or placebo (n=146). Following exclusions due to protocol violations, we analysed 214 patients (114 extrafine inhaled corticosteroids and 100 placebo). We observed a significant interaction between baseline F e NO and treatment group for every 10 ppb increase in baseline F e NO, with the change in ACQ7 greater in the extrafine inhaled corticosteroids group than in the placebo group (difference between groups 0·071, 95% CI 0·002 to 0·139; p=0·044). The most common adverse events were nasopharyngitis (18 [12%] patients in the treatment group vs 13 [9%] in the placebo group), infections and infestations (25 [17%] vs 21 [14%]), and respiratory, thoracic, and mediastinal disorders (13 [9%] vs 17 [12%]). Interpretation F e NO measurement is an easy and non-invasive tool to use in clinical practice in patients with non-specific respiratory symptoms to predict response to inhaled corticosteroids. Further research is needed to examine its role in patients with evidence of other airway diseases, such as chronic obstructive pulmonary disease. Funding Sponsored by OPRI with partial funding by Circassia and study drugs provided by TEVA. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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24. Microbiome-immune interactions and relationship to asthma severity.
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Trujillo, Juan, Lunjani, Nonhlanhla, Ryan, Dermot, and O'Mahony, Liam
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- 2022
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25. How to identify and manage seasonal allergic rhinitis.
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Ryan, Dermot
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ATROPHIC rhinitis ,INTRANASAL medication ,ADRENOCORTICAL hormones ,ANTIHISTAMINES ,COMBINED modality therapy ,DRUGS ,SEASONAL variations of diseases ,ALLERGIC rhinitis ,IMMUNOTHERAPY ,MEDICAL history taking ,PATIENT compliance ,PATIENT education ,POLLEN ,DISEASE management ,NASAL vasoconstrictors ,NASAL irrigation ,SYMPTOMS ,DIAGNOSIS - Abstract
Allergic rhinitis (AR) is a common disorder which has a major impact on the lives of sufferers and families. Although currently there is no cure for this disease, a variety of therapeutic interventions can alleviate the symptoms. It is important that nurses are able to differentiate allergic and non-allergic rhinitis (NAR) from viral upper respiratory tract infections (URTIs) in order to best manage their patients. It is also necessary to ask appropriate questions of those patients attending for asthma review, as they may have unrecognised and untreated disease. Familiarity with the range of medications and their administration is advocated. Patients with troublesome, non-responding symptoms need to be referred, as do those with red flag signs. [ABSTRACT FROM AUTHOR]
- Published
- 2016
26. Harm Reduction in Process: The ACON Rovers, GHB, and the Art of Paying Attention
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Gonçalves, Davi Martinelli, Kolstee, Johann, Ryan, Dermot, and Race, Kane
- Abstract
In recent work on environmental and health risks, Isabelle Stengers has suggested that governing logics have been seized by a strange injunction: “the right not to pay attention.” She characterizes “paying attention” as an art that brings into play connections we are in the habit of keeping separate. In this article, we use this insight to characterize different forms of prevention in the drugs field, arguing that “modes of attention” are an important consideration for harm reduction and counterpublic health. Our case study centers on the ACON Rovers, a team of volunteers who rove around gay dance events on the lookout for people in trouble. Through certain “arts of interception” and through an immanent practice of working with possibilities, the Rovers aim to avert certain dangers, especially those associated with use of the drug gamma-hydroxybutyric acid. But doing this work well involves a certain mode of attending to risk, derived from embodied knowledge, that has regard to the affective relations of surveillance. In this article, we seek to describe and theorize the work of the ACON Rovers. We discuss the historical emergence of the program, the forms of knowledge it draws upon and mobilizes, the attention the project pays to affective relations between different actors in the party environment, and the mechanisms the project has installed to assess and reflect upon its work. Since they seek to intervene in drug effects, we argue that the Rovers are engaged in ontological work. Their mode of operation can be contrasted with that of drug enforcement, which often assumes “the right not to pay attention.”
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- 2016
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27. The Seven Stages of Man: The Role of Developmental Stage on Medication Adherence in Respiratory Diseases
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Costello, Richard W., Foster, Juliet M., Grigg, Jonathan, Eakin, Michelle N., Canonica, Walter, Yunus, Fasail, and Ryan, Dermot
- Abstract
The circumstances and drivers of the decision to initiate, implement, or persist with a medication differ for individuals at each developmental stage. For school-age children with asthma, the social environment of their family's cultural beliefs and the influence of peer networks and school policies are strong determinants of medication adherence. The stage of adolescence can be a particularly challenging time because there is a reduction in parental supervision of asthma management as the young person strives to become more autonomous. To illustrate the importance of such factors, adherence interventions in children and young adults with asthma have used peer-based supports and social supports, particularly social media platforms. In older patients, it is internal rather than external factors and age-related decline that pose challenges to medication adherence. Seniors face the challenges of polypharmacy, reduced social support, increased isolation, and loss of cognitive function. Strategies to promote adherence must be tailored to the developmental stage and respective behavioral determinants of the target group. This review considers the different attitudes toward medication and the different adherence behaviors in young and elderly patients with chronic respiratory conditions, specifically asthma and chronic obstructive pulmonary disease. Opportunities to intervene to optimize adherence are suggested.
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- 2016
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28. Enhancing Respiratory Medication Adherence: The Role of Health Care Professionals and Cost-Effectiveness Considerations
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van Boven, Job F.M., Ryan, Dermot, Eakin, Michelle N., Canonica, Giorgio W., Barot, Aji, and Foster, Juliet M.
- Abstract
Adherence to medication comprises a multiphased temporal process involving (1) initiation of prescribed therapy, (2) implementation as prescribed, and (3) subsequent persistence. Medication adherence remains suboptimal in most patients with long-term respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). Interventions have been shown to effectively improve treatment initiation, implementation, and persistence when delivered at the health care professional level or the system level, but demonstration of the cost-effectiveness of these interventions is necessary to ensure their widespread use. This review summarizes how health care professionals can intervene to improve medication adherence in patients with asthma and COPD, provides some examples of effective primary care interventions, and illustrates some of the challenges to optimal implementation arising from cost-effectiveness modeling. Improving adherence is shown to be an economically viable treatment option for patients with asthma and COPD, but there are differences in the health economics pertaining to each condition and setting that can affect whether an intervention is considered cost-effective. Targeting adherence interventions at patients with the greatest to gain, and tailoring them to individual patient needs, may help to optimize cost-effectiveness ratios and improve the probability of positive reimbursement decisions, systemwide implementation, and resultant health benefits.
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- 2016
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29. Opportunities to diagnose chronic obstructive pulmonary disease in routine care in the UK: a retrospective study of a clinical cohort.
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Jones, Rupert C M, Price, David, Ryan, Dermot, Sims, Erika J, von Ziegenweidt, Julie, Mascarenhas, Laurence, Burden, Anne, Halpin, David M G, Winter, Robert, Hill, Sue, Kearney, Matt, Holton, Kevin, Moger, Anne, Freeman, Daryl, Chisholm, Alison, and Bateman, Eric D
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OBSTRUCTIVE lung disease diagnosis ,MEDICAL care ,RETROSPECTIVE studies ,COHORT analysis ,COMORBIDITY ,MEDICAL records - Abstract
Summary: Background: Patterns of health-care use and comorbidities present in patients in the period before diagnosis of chronic obstructive pulmonary disease (COPD) are unknown. We investigated these factors to inform future case-finding strategies. Methods: We did a retrospective analysis of a clinical cohort in the UK with data from Jan 1, 1990 to Dec 31, 2009 (General Practice Research Database and Optimum Patient Care Research Database). We assessed patients aged 40 years or older who had an electronically coded diagnosis of COPD in their primary care records and had a minimum of 3 years of continuous practice data for COPD (2 years before diagnosis up to a maximum of 20 years, and 1 year after diagnosis) and at least two prescriptions for COPD since diagnosis. We identified missed opportunites to diagnose COPD from routinely collected patient data by reviewing patterns of health-care use and comorbidities present before diagnosis. We assessed patterns of health-care use in terms of lower respiratory consultations (infective and non-infective), lower respiratory consultations with a course of antibiotics or oral steroids, and chest radiography. If these events did not lead to a diagnosis of COPD, they were deemed to be missed opportunities. This study is registered with ClinicalTrials.gov, number NCT01655667. Findings: We assessed data for 38 859 patients. Opportunities for diagnosis were missed in 32 900 (85%) of 38 859 patients in the 5 years immediately preceding diagnosis of COPD; in 12 856 (58%) of 22 286 in the 6–10 years before diagnosis, in 3943 (42%) of 9351 in the 11–15 years before diagnosis; and in 95 (8%) of 1167 in the 16–20 years before diagnosis. Between 1990 and 2009, we noted decreases in the age at diagnosis (0·05 years of age per year, 95% CI 0·03–0·07) and yearly frequency of lower respiratory prescribing consultations (rate ratio 0·982 opportunities per year, 95% CI 0·979–0·985). Prevalence of all comorbidities present at COPD diagnosis increased except for asthma and bronchiectasis, which decreased between 1990 and 2007, from 281 (33·4%) of 842 patients to 451 of 1465 (30·8%) for asthma, and from 53 of 842 (6·3%) to 53 of 1465 (3·6%) for bronchiectasis. In the 2 years before diagnosis, of 6897 patients who had had a chest radiography, only 2296 (33%) also had spirometry. Interpretation: Opportunities to diagnose COPD at an earlier stage are being missed, and could be improved by case-finding in patients with lower respiratory tract symptoms and concordant long-term comorbidities. Funding: UK Department of Health, Research in Real Life. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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30. Improved skills and training could reduce admissions for COPD.
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Ryan, Dermot
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- 2013
31. Advances in pharmacotherapy for the treatment of allergic rhinitis; MP29-02(a novel formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) fills the gaps
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Bousquet, Jean, Bachert, Claus, Bernstein, Jonathan, Canonica, G Walter, Carr, Warner, Dahl, Ronald, Demoly, Pascal, Devillier, Philippe, Hellings, Peter, Fokkens, Wytske, Klimek, Ludger, Lieberman, Phil, Meltzer, Eli, Price, David, Ryan, Dermot, and Wahn, Ulrich
- Abstract
Introduction:Effective pharmacologic treatment exists for most patients suffering from allergic rhinitis (AR). However, both in clinical trials and in real-life studies, many patients are dissatisfied with treatment. Physicians often use multiple therapies, in an attempt to improve symptom control, often with limited evidence of success. Novel treatment options are needed and must consider unmet medical needs.Areas covered:This article reviews the clinical data for a new AR treatment. MP29-02(Dymista®, Meda, Solna, Sweden) contains azelastine hydrochloride (AZE) and fluticasone propionate (FP), in a novel formulation and delivered in an improved device as a single nasal spray. It has shown superior efficacy in AR patients than either commercially available AZE or FP monotherapy for both nasal and ocular symptom relief, regardless of disease severity. MP29-02 also provided more effective and rapid symptom relief than either AZE or FP monotherapy delivered in the MP29-02 formulation and device. However, the effect was less than that observed versus commercial comparators, suggesting the impact of formulation and device on clinical efficacy.Expert opinion:MP29-02 simplifies AR management, surpassing the efficacy of gold standard treatment, intranasal corticosteroids (INS), for the first time. It is indicated for the treatment of moderate-to-severe seasonal allergic rhinitis and perennial allergic rhinitis when monotherapy with either intranasal antihistamine or INS is NOT considered sufficient. Most patients present with moderate/severe disease, with evidence of current or previous treatment insufficiency. MP29-02 should be the treatment of choice for these patients.
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- 2015
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32. The challenge of recruiting in primary care for a trial of telemonitoring in asthma: an observational study.
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Malhotra, Shweta, Musgrave, Stanley D., Pinnock, Hilary, Price, David, and Ryan, Dermot P.
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RANDOMIZED controlled trials ,PRIMARY care ,ASTHMA ,BRONCHIAL diseases ,OBSTRUCTIVE lung diseases - Abstract
Aim: Achieving target recruitment in randomized controlled trials (RCTs) is challenging. This paper compares our experience of recruiting for an RCT with the predictions made in our proposal. Methods: Participating UK primary care practices searched their computer databases to identify patients (12 years and over) with asthma who may be poorly controlled. Postal invitations were sent to all patients identified. Respondees were prescreened by phone, to assess their asthma control and establish their mobile phone suitability. Potentially eligible patients were booked for a trial recruitment visit.Results: We recruited 288 patients (2.4% of those invited) across 32 practices, with a total list size of 311,926 patients. This compares to our predicted recruitment of 312 patients from a population of 72,000 patients in six to eight practices. In addition to the recognized problem of poor response rates, the major challenges were insufficiently discriminating computer searches and incompatibilities between mobile phone handsets, networks and the asthma application. Conclusion: Our data have implications for clinicians, managers, and researchers in primary care. Researchers in this area may wish to consider our data when designing their recruitment strategies. Improved coding of asthma morbidity data in clinical practice would ease identification of poorly controlled patients, both for clinical interventions and recruitment to trials. If telehealth is to become mainstream, there needs to be standardization of applications, operating platforms, and network capabilities [ABSTRACT FROM AUTHOR]
- Published
- 2012
33. Sub-lingual Immunotherapy: World Allergy Organization Position Paper 2009.
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Bousquet, Philippe J., Cox, Linda S., Durham, Stephen R., Nelson, Harold S., Passalacqua, Giovanni, Ryan, Dermot P., Brozek, Jan L., Compalati, Enrico, Dahl, Ronald, Delgado, Luis, van Wijk, Roy Gerth, Gower, Richard G., Ledford, Dennis K., Rosario Filho, Nelson, Valovirta, Erkka J., Yusuf, Osman M., Zuberbier, Torsten, Akhanda, Wahiduzzaman, Almarales, Raul Castro, and Ansotegui, Ignacio
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IMMUNOTHERAPY ,MEDICAL care ,IMMUNE system ,IMMUNOLOGIC diseases ,NATURAL immunity ,ALLERGENS - Abstract
The article presents the 2009 issue of the "World Allergy Organization." It discusses the use of sub-lingual immunotherapy (SLIT) in medical care particularly its clinical application for physicains who are focusing on the development of immune system resistance. Moreover, it also provides an overview on the functions of subcutaneous immunotherapy and other routes of immunotherapy administration in treating severe diseases due to allergens.
- Published
- 2009
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34. The Queen's Case.
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Ryan, Dermot
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ACTIONS & defenses (Law) ,COMMON law ,CROSS-examination ,ADULTERY - Abstract
This article explores The Queen's Case (1820) 2 Brod & B 284; 129 ER 976. As well as being a sensational episode in English history, The Queen's Case is authority for the basic rule of the common law that a witness cannot be asked any question about the contents of a document, unless the document is first shown to the witness and put in evidence as part of the case of the party represented by the cross-examiner. An undesirable consequence of this rule was that the party represented by the cross-examiner was forced into evidence, with consequential effects on the order of final address. This article provides some highlights of Queen Caroline's trial for adultery, in particular the sometimes questionable conduct and tactics of her legal team, before turning to the significant implications of the rule and its descendants for the conduct of modern litigation. [ABSTRACT FROM AUTHOR]
- Published
- 2009
35. European forest ecosystems: building the future on the legacy of the past.
- Author
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Farrell, Edward P., Führer, Erwin, Ryan, Dermot, Andersson, Folke, Hüttl, Reinhard, and Piussi, Pietro
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FOREST management ,FORESTS & forestry ,FOREST ecology ,HISTORY - Abstract
Discusses forest use and management in Europe from ancient times until the present. Evolution of forest management and its influence on the present-day sustainability of forests; Move beyond regulation of exploitation towards wood production; Paradigm shifts and the development of scientific forest management; Human impact on the sustainability of forest ecosystems; Concepts in sustainability.
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- 2000
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36. Trauma and PTSD rates in an irish psychiatric population
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Wilson, Fiona E, Hennessy, Eilis, Dooley, Barbara, Kelly, Brendan D, and Ryan, Dermot A
- Abstract
Although Western mental health services are increasingly finding themselves concerned with assisting traumatized individuals migrating from other countries, trauma and posttraumatic stress disorder (PTSD) are under-detected and undiagnosed in psychiatric populations. This study examined and compared rates of traumatic experiences, frequency of traumatic events, trauma symptomatology levels, rates of torture, rates of PTSD and chart documentation of trauma and PTSD between (a) Irish and migrant service-users and (b) forced migrant and voluntary migrant service-users in Dublin, Ireland. Data were gathered from 178 psychiatric outpatients attending using a sociodemographic questionnaire, the Harvard Trauma Questionnaire-Revised Cambodian Version and the SCID-I/P. A substantial number of service-users had experienced at least one lifetime trauma (71.3%), and a high percentage of both the Irish (47.4%) and migrant groups (70.3%) of service-users had experienced two or more events. Overall, analyses comparing rates between Irish, forced migrant and voluntary migrant service-users found that forced migrants displayed more traumatic life events, posttraumatic symptoms, and higher levels of PTSD than their voluntary migrant and Irish counterparts, with over 50% experiencing torture prior to arrival in Ireland. The lifetime rate of PTSD in the overall sample was 15.7% but only 53.57% of cases were documented in patient charts. The results of this study are informative about the nature and extent of the problem of trauma and PTSD among migrant mental health service users as well as highlighting the under-detected levels of trauma among native-born service users.
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- 2013
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37. Consommation de soins des patients BPCO en France et au Royaume-Uni entre 2008 et 2017, et coûts associés
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Belhassen, Manon, Whittaker, Hannah, Nolin, Maeva, Dalon, Faustine, Micallef, Claire Marant, Deslée, Gaëtan, Pison, Christophe, Ryan, Dermot, Quint, Jennifer, and Van Ganse, Eric
- Abstract
Le Royaume-Uni (UK) présente des taux de mortalité et d’hospitalisation pour Broncho Pneumopathie Chronique Obstructive (BPCO) plus élevés que ceux de la France. Ces différences pourraient être dues à des différences de prise en charge : le but de cette étude était de décrire la consommation de soins des patients BPCO et les coûts associés dans les 2 pays.
- Published
- 2021
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38. Psychological Distress and the Asylum Process
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Ryan, Dermot A., Benson, Ciarán A., and Dooley, Barbara A.
- Abstract
Although asylum seeking has become a major political issue in the Western world, research on its psychological impact is still in its infancy. This study examined levels and predictors of distress among a community sample of persons who have sought asylum in Ireland. A key aim was to provide a longitudinal analysis of the relationship between legal status security and psychological distress. Distress was measured by the Symptom Checklist-90-Revised at Time 1 (N162) and its shorter version (the Brief Symptom Inventory) at Time 2 (N70). Levels of severe distress were high at both baseline (46%) and follow-up (36%). The only persons to show a decrease in distress were those who had obtained a secure legal status (e.g., refugee status or residency) between the study phases. Distress risk factors included female gender, an insecure legal status, separation from children, discrimination, and postmigration stress. Protective factors were social support (Time 1) and the presence of a partner. The findings suggest that asylum seekers are a high-risk group for distress. This risk can be reduced by appropriate policy changes and interventions to increase social resources.
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- 2008
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39. Alvesco: a once‐daily steroid for asthma prophylaxis
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Ryan, Dermot
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Ciclesonide is a novel inhaled steroid with high lung deposition and a once‐daily dosage.Dr Ryan considers its properties and its potential role in asthma prophylaxis. Copyright © 2006 Wiley Interface Ltd
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- 2006
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40. ONLINE EDUCATION SIGNIFICANTLY IMPROVES KNOWLEDGE AND COMPETENCE IN MANAGING COPD WITH DUAL BRONCHODILATOR AND TRIPLE COMBINATION THERAPIES
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Rohani-Montez, Christy, Lambert, Trevor, Guerra, Wilma, AMARA, Walid, Phillips, Caroline, and Ryan, Dermot
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- 2019
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41. High-Resolution Mapping using SAM Surveys over the Bogada Bore Gold Prospect, Western Australia
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Cooper, Mathew, Meyers, Jayson, Ryan, Dermot, and Compston, David
- Abstract
AbstractThe Bogada Bore prospect lies immediately to the northeast of the Jundee gold deposit, in the north-west margin of the Archaean Yandal Greenstone Belt, Western Australia. The prospect has a long exploration history and has undergone extensive but variably effective drilling. The gold mineralisation at Bogada Bore shares many common characteristics with the Jundee and Nimary deposits, and is controlled by predominantly brittle structures, with high-grade shoots occurring along the intersection of structures, or by the intersection of structures with dacitic porphyry intrusions.Outcrop is sparse with more than 90% of the area under thin colluvial cover and regolith weathering commonly down to 50 m or more. Previous geological interpretations have been mainly generated from drilling information, with the use of geophysics limited to a single high-resolution aeromagnetic survey conducted in 1994. This survey was useful for refining the existing geological interpretation by highlighting regional structures, geological boundaries, and magnetic trends, but it failed to delineate the small-scale structures which control gold mineralisation at Bogada Bore.Sub-Audio Magnetic (SAM) surveys were trialled over the prospect area, and have been able to delineate numerous regional and small-scale structures that are shown to correlate with gold mineralisation over several areas. These surveys have also provided the basis for a new and more detailed geological interpretation in conjunction with a gravity survey and the existing aeromagnetic and drilling data.
- Published
- 2005
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42. Potential Severe Asthma Hidden in UK Primary Care
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Ryan, Dermot, Heatley, Heath, Heaney, Liam G., Jackson, David J., Pfeffer, Paul E., Busby, John, Menzies-Gow, Andrew N., Jones, Rupert, Tran, Trung N., Al-Ahmad, Mona, Backer, Vibeke, Belhassen, Manon, Bosnic-Anticevich, Sinthia, Bourdin, Arnaud, Bulathsinhala, Lakmini, Carter, Victoria, Chaudhry, Isha, Eleangovan, Neva, FitzGerald, J. Mark, Gibson, Peter G., Hosseini, Naeimeh, Kaplan, Alan, Murray, Ruth B., Rhee, Chin Kook, Van Ganse, Eric, and Price, David B.
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Severe asthma may be underrecognized in primary care.
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- 2021
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43. A Proposal from the Montpellier World Health Organization Collaborating Centre for Better Management and Prevention of Anaphylaxis
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Tanno, Luciana Kase, Touati, Nidhal, Allichon, Salome, Martin, Bryan, Ebisawa, Motohiro, Ansotegui, Ignacio, Sanchez-Borges, Mario, Cardona, Victoria, Greenberger, Paul A., Ryan, Dermot, Pouessel, Guillaume, Beaudouin, Etienne, Renaudin, Jean-Marie, Thien, Francis, Chang, Yoon-Seok, Pawankar, Ruby, Gomez, Maximiliano, Jares, Edgardo, Staffeld, Patricia Latour, Agache, Ioana, Muraro, Antonella, Mahr, Todd A., Sublett, James, Casale, Thomas, Lang, David, and Demoly, Pascal
- Abstract
Since the first description of anaphylaxis in 1902, its clinical importance as an emergency condition has been recognized worldwide. Anaphylaxis is a severe, potentially life-threatening systemic hypersensitivity reaction characterized by rapid onset and the potential to endanger life through respiratory or circulatory compromise. It is usually, although not always, associated with skin and mucosal changes. Although the academic/scientific communities have advocated to promote greater awareness and protocols for the management of anaphylaxis based on best evidence, there are few efforts documenting feedback as to the success of these efforts. In this article, we review the key unmet needs related to the diagnosis and management of anaphylaxis, and propose a public health initiative for prevention measures and a timetable action plan that intends to strengthen the collaboration among health professionals and especially primary care physicians dealing with anaphylaxis, which can encourage enhanced quality of care of patients with anaphylaxis. More than calling for a harmonized action for the best management of anaphylaxis to prevent undue morbidity and mortality, the Montpellier World Health Organization Collaborating Centre here proposes an action plan as a baseline for a global initiative against anaphylaxis. We strongly believe that these collaborative efforts are a strong public health and societal priority that is consistent with the overarching goals of providing optimal care of allergic patients and best practices of allergology.
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- 2021
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44. Hormone replacement therapy and risk of severe asthma exacerbation in peri-menopausal and post-menopausal women: 17-year national cohort study
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Nwaru, Bright I., Shah, Syed A., Tibble, Holly, Pillinger, Rebecca, McLean, Susannah, Ryan, Dermot, Critchley, Hilary, Hawrylowicz, Catherine M., Simpson, Colin R., Soyiri, Ireneous N., Appiagyei, Francis, Price, David, and Sheikh, Aziz
- Abstract
The impact of hormone replacement therapy (HRT) on clinical outcomes in menopausal women is uncertain.
- Published
- 2021
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45. Current Breakthrough in Computer Imaging
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Ryan, Dermot
- Published
- 1990
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46. Book Review: THE MYSTERY OF THE REDEMPTION, by L. Richard; Helicon Press, Baltimore-Dublin, n.d.; pp. 358. Price 35/-. ADAM AND THE FAMILY OF MAN, by J. de Fraine; Alba House, New York 1965; pp. 287. Price S4.95. LA BIBLE, PAROLE DE DIEU, by P. Grelot; Desclée, Paris 1965; pp. 418. Price 330 Fr. B
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Ryan, Dermot J.
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- 1967
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47. Notes and Comments
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Ryan, Dermot
- Published
- 1965
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48. Book Reviews: DIE KIRCHE IM NEUEN TESTAMENT. By Rudolf Schnackenburg. Quaestiones Disputatae. No. 14. Herder, Freiburg, 1961. Pp. 172. LA THEOLOGIE DU NOUVEAU TESTAMENT. By Rudolf Schnackenburg. Desclée de Brouwer, 1961. Studia Neotestamentica. Subsidia I. Pp. 123. WORSHIP IN THE NEW TESTAMENT. By D. Gerhard Delling. Translated by Percy Scott, D.D. Darton, Longman and Todd, London, 1962. Pp. xiii and 191. Price 35/-
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Ryan, Dermot J.
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- 1963
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49. Developing regional responses to HIV in the era of combination prevention.
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Ryan, Dermot
- Abstract
The article focuses on the development of regional collective responses against HIV in Sydney, New South Wales. It says that most people affected by HIV in the state are gay men. It says that several measures established in the United Nations 2011 Political Declaration on HIV/AIDS (UNPD) include reducing the sexual transmission of HIV among gay men and men who have sex with men (MSM), injecting drug users, and sustaining the virtual elimination of mother-to-child transmission.
- Published
- 2012
50. Relationship of Inhaled Corticosteroid Adherence to Asthma Exacerbations in Patients with Moderate-to-Severe Asthma
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Papi, Alberto, Ryan, Dermot, Soriano, Joan B., Chrystyn, Henry, Bjermer, Leif, Rodríguez-Roisin, Roberto, Dolovich, Myrna B., Harris, Mark, Wood, Lucy, Batsiou, Maria, Thornhill, Susannah I., and Price, David B.
- Abstract
Patients with asthma and elevated blood eosinophils are at increased risk of severe exacerbations. Management of these patients should consider nonadherence to inhaled corticosteroid (ICS) therapy as a factor for increased exacerbation risk.
- Published
- 2018
- Full Text
- View/download PDF
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